This text has been reviewed in accordance with Science X’s editorial course of
and insurance policies.
Editors have highlighted the next attributes whereas making certain the content material’s credibility:
fact-checked
peer-reviewed publication
trusted supply
proofread
Okay!
Meningiomas are graded by microscopic look, price of development and tendency to invade different tissues. Credit score: Nationwide Most cancers Institute
× shut
Meningiomas are graded by microscopic look, price of development and tendency to invade different tissues. Credit score: Nationwide Most cancers Institute
Extended use of sure progestogen hormone medicine is related to an elevated threat of growing a kind of mind tumor generally known as an intracranial meningioma, finds a research from France revealed by The BMJ at present.
The researchers say this research is the primary to evaluate the danger related to progestogens utilized by tens of millions of girls worldwide, and additional research are urgently wanted to achieve a greater understanding of this threat.
Progestogens are just like the pure hormone progesterone, that are extensively used for gynecological circumstances akin to endometriosis and polycystic ovary syndrome, and in menopausal hormone remedy and contraceptives.
Meningiomas are principally non-cancerous tumors within the layers of tissue (meninges) that cowl the mind and spinal twine. Components akin to older age, feminine intercourse, and publicity to a few high-dose progestogens (nomegestrol, chlormadinone, and cyproterone acetate) are already recognized to extend the danger of meningioma.
However there are a lot of different progestogens for which the danger of meningioma related to their use has not been estimated individually.
To handle this data hole, researchers got down to consider the actual life threat of intracranial meningioma requiring surgical procedure in ladies related to use of a number of progestogens with totally different routes of administration. They used knowledge from the French nationwide well being knowledge system (SNDS) for 18,061 ladies (common age 58) who underwent intracranial meningioma surgical procedure from 2009–2018.
Every case was matched to 5 management ladies with out intracranial meningioma (whole 90,305) by yr of start and space of residence.
The progestogens examined have been progesterone, hydroxyprogesterone, dydrogesterone, medrogestone, medroxyprogesterone acetate, promegestone, dienogest, and levonorgestrel intrauterine programs. For every progestogen, use was outlined as a minimum of one prescription within the yr earlier than hospital admission or inside 3-5 years for levonorgestrel intrauterine programs.
Use of a minimum of one of many three high-dose progestogens recognized to extend the danger of meningioma within the 3 years earlier than hospital admission was additionally recorded to attenuate bias.
After the researchers took account of different probably influential elements, they discovered that extended use (a yr or extra) of medrogestone was related to a 4.1-fold elevated threat of intracranial meningioma requiring surgical procedure. Extended use of medroxyprogesterone acetate injection was related to a 5.6-fold elevated threat, and extended use of promegestone was linked to a 2.7-fold elevated threat.
There gave the impression to be no such threat for lower than one yr of use of those progestogens.
As anticipated, there was additionally an extra threat of meningioma for girls uncovered to chlormadinone acetate, nomegestrol acetate, and cyproterone acetate, all of that are recognized to extend the danger of meningioma. Nevertheless, outcomes confirmed no extra threat of meningioma for progesterone, dydrogesterone, or the extensively used hormonal intrauterine programs, whatever the dose of levonorgestrel they contained.
Extra info:
Use of progestogens and the danger of intracranial meningioma: a nationwide case-control research, The BMJ (2024). DOI: 10.1136/bmj-2023-078078
Journal info:
British Medical Journal (BMJ)