Lexapro, Paxil and Cymbalta carry the next threat of packing on kilos than Zoloft, whereas Wellbutrin customers are much less more likely to acquire weight, based on a brand new examine of eight well-liked antidepressants.
Harvard Pilgrim Well being Care Institute (HPHCI) researchers analyzed the weights of greater than 183,000 grownup antidepressant customers six months, a 12 months and two years after they began taking the medication.
At six months of utilization, Lexapro, Paxil and Cymbalta customers had been 10% to fifteen% extra more likely to acquire a minimum of 5% of their beginning weight than Zoloft shoppers, the examine discovered. PRN
Knowledge from taking Celexa (citalopram), Lexapro (escitalopram), Prozac (fluoxetine), Paxil (paroxetine), Wellbutrin (bupropion), Cymbalta (duloxetine) and Effexor (venlafaxine) was in comparison with Zoloft (sertraline), which is essentially the most prescribed antidepressant within the US.
At six months, Lexapro, Paxil and Cymbalta customers had been 10% to fifteen% extra more likely to acquire a minimum of 5% of their beginning weight than Zoloft shoppers.
Prozac was not related to a six-month weight change, whereas Wellbutrin customers had been 15% much less more likely to expertise a 5% weight acquire. Wellbutrin continued to be related to the least weight acquire on the one- and two-year marks.
Wellbutrin was related to the least weight acquire on the six-month, one- and two-year marks. Getty Pictures
The findings had been revealed this week in the Annals of Inner Drugs.
The researchers credited Wellbutrin’s skill to extend ranges of dopamine and norepinephrine within the mind, which enhance wakefulness and application.
The drug — used to deal with melancholy and seasonal affective dysfunction and assist folks quit smoking — has additionally been proven to stimulate the central melanocortin system, which regulates urge for food, vitality stability and physique weight.
The examine outcomes come amid rising antidepressant use, particularly amongst younger adults and youths.
One examine discovered that about 14% of US adults take an antidepressant. The HPHCI researchers famous that individuals typically cease utilizing the drug in the event that they expertise weight acquire.
“This examine offers essential real-world proof concerning the quantity of weight acquire that needs to be anticipated after beginning a number of the most typical antidepressants,” mentioned lead writer Joshua Petimar, a Harvard Medical College assistant professor of inhabitants medication.
“Clinicians and sufferers can use this data, amongst different elements, to assist determine on the proper alternative for them,” he added.
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Biggest threat of a minimum of 5% weight acquire at six months of use
Lexapro
Paxil
Cymbalta
Effexor
Celexa
Zoloft (baseline)
Prozac
Wellbutrin